Andre Jackson was born the first of two children in the small Arkansas Delta town of Forrest City. His father is of African American and Native American (Lakota Sioux) descent and his mother is of African American and Irish descent. He and his sister Nikky spent much of their childhood in Forrest City being raised by their paternal grandmother.

For more than a decade, Andre has performed extensively in award-winning theatrical productions nationwide. Shortly after attending the American Academy of Dramatic Arts (AADA) in Los Angeles, he was cast in Mark Stein’s Direct from Death Row- The Scottsboro Boys. For his performance in The Scottsboro Boys, Andre received the Los Angeles Drama Critics Circle Award for Best Featured Actor and, alongside the rest of the cast, Best Ensemble Award. He was an NAACP Theatre Award and Los Angeles Ovation Award winner for his gripping role in August Wilson’s Joe Turner’s Come and Gone and was nominated for Best Lead Actor at the BroadwayWorld Awards for his lead role as “Simba” in the Tony Award winning Disney’s The Lion King.

In addition to television and film appearances in the Amazon series BLACK, NBC's Law & Order: SVU, and Netflix's Luke Cage, Andre is the writer, producer and star of the multiple award-winning film STOP. He is also the Overall Winner of the 2020 Filmmatic TV Pilot Award for his original series pilot Boley U.S.A. and a television writer for CBS/Paramount and NBC/Universal.

A former Marine who has traveled all over the world, Andre now splits his time between New York City, Memphis and Los Angeles, where he primarily resides with his wife (a writer) and son (an aspiring chef/astronaut).